This is why I love the folks at Bethesda:
So there I am, fighting against a bunch of raiders in Fallout 4. They're ducking behind cover and shooting and I'm kinda ducking behind cover and shooting when, amid all of the other things the raiders are shouting, I hear one of them yell out, "Aggghhh. I got hit in the knee!"
So, if you've never played Skyrim, it's just another throw-away line like, "Keep firing!" But I have. A lot. So of course I got killed shortly after that because I was too busy laughing to even hit the pause button.
If you have no idea what I'm talking about, hit up Google with the phrase "arrow in the knee".